In Victorian London; the most famous detective Sherlock Holmes and his team are hunting the mysterious criminal Moriarty. The chase takes place across the city; and the detectives have to work together to catch him.

In Scotland Yard: Sherlock Holmes Edition; a new version of Scotland Yard; players slip into the roles of Sherlock Holmes; his brother Mycroft; and his companions Dr. Watson; Inspector Lestrade; and Irene Adler and pursue Moriarty throughout the streets of London. The pursued Moriarty can be seen only rarely; and he can secretly use a hot air balloon to cover his tracks and move elsewhere quickly. If he remains undetected to game's end; he wins; so the detectives need to work together and use their special abilities skillfully to bring him to justice.