Due to some magical mayhem, the Transformers find themselves in Equestria, and the Decepticons have teamed up with nefarious Pony Villains, which can't lead to anything good.

InMy Little Pony: Adventures in Equestria Deck-Building Game Collision Course Expansion, the Mane Six (and Spike!) team up with the Autobots as two-in-one character cards. Use the Autobots abilities by generating Energon on cards or getting an energy boost by eating a Sugar Cube instead.